Centro Nazionale per la
Cura dei Tumori dell'Ipofisi

Direttore: Prof. P. Mortini

Suprasellar granular cell tumor of the neurohypophysis: surgical outcome of a very rare tumor
Gagliardi F, Spina A, Barzaghi LR, Bailo M, Losa M, Terreni MR, Mortini P.

Pituitary. 2016 Jun;19(3):277-85

Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas
Mortini P., Gagliardi, F., Bailo, M., (...), Falini, A., Losa, M.

Endocrine. 2016 Jan;51(1):148-62.

Is the incidence of differentiated thyroid cancer increased in patients with TSH-secreting adenoma? Report of three cases from a large consecutive series of TSH-oma
Perticone F, Pigliaru F, Mariotti S, Deiana L, Furlani L, Mortini P, Losa M

Thyroid. 2015 Apr;25(4):417-24

Cons: endoscopic endonasal transsphenoidal pituitary surgery is not superior to microscopic transsphenoidal surgery for pituitary adenomas
Mortini P.

Endocrine. 2014 Nov;47(2):415-20.

Thyrotropin-secreting pituitary adenomas: outcome of pituitary surgery and irradiation
Malchiodi, E., Profka, E., Ferrante, E., (...), Mortini P, Spada, A., Mantovani, G.

Journal of Clinical Endocrinology and Metabolism 99 (6), pp. 2069-2076

Presentation and surgical results of incidentally discovered nonfunctioning pituitary adenomas: evidence for a better outcome indipendently of other patients’ characteristics.
Ferrari L, Pistocchi A, Libera L, Boari N, Mortini P, Bellipanni G, Giordano A, Cotelli F, Riva P.

European Journal of Endocrinology: 2013; 169(6): 735-742

Surgical strategies and modern therapeutic options in the treatment of craniopharyngiomas. (Review)
Mortini P, Gagliardi F, Boari N, Losa M.

Critical Reviews in Oncology/Hematology: 2013; 88(3): 514-529

Solitary clival plasmocytomas: Misleading clinical and radiological features of a rare pathology with a specific biological behaviour
Gagliardi F, Losa M, Boari N, Spina A, Reni M, Terreni MR, Mortini P.

Acta Neurochir (Wien). 2013 Oct;155(10):1849-56.

Suprasellar granular cell tumor of the neurohypophysis in a child: usual presentation in pediatric age of a rare tumor.
Gagliardi F, Losa M, Boari N, Franzin A, Pozzobon G, Weber G, Mortini P.

Child's Nervous System : 2013; 29(6): 1031-1034

Effects of AMPK activations and combined treatment with AMPK activators and somatostatin on hormone secretion and cell growth in cultured GH-secreting pituitaruy tumor cells
Tulipano G, Faggi L, Losa M, Mortini P, Spinello M, Sibilia V, Pagani F, Cocchi D, Giustina A.

Mol. Cell. Endocrinol.: 2013; 365(2): 197-206

The combined interhemispheric subcommissural translaminaterminalis approach for large craniopharyngiomas
Mortini P, Gagliardi F, Boari N, Roberti F, Caputy A.J.

World Neurosurgery 2013 80:1-2(160-166)

Dosimetric factors associated with pituitary function after Gamma Knife Surgery of pituitary adenomas
Sicignano G, Losa M, Del Vecchio A, Cattaneo GM, Picozzi P, Bolognesi A, Mortini P, Calandrino R.

Radiother Oncol. 2012 Jul;104(1):119-24.106.

Visual outcome after fronto-temporo-orbito-zygomatic approach combined with early extradural and intradural optic nerve decompression in tuberculum and diaphragma sellae meningiomas
Mortini P, Barzaghi LR, Serra C, Orlandi V, Bianchi S, Losa M.

Clin Neurol Neurosurg. 2012 Jul;114(6):597-606.103.

Prognostic factors of visual field improvement after trans-sphenoidal approach for pituitary macroadenomas: review of the literature and analysis by quantitative method
Barzaghi LR, Medone M, Losa M, Bianchi S, Giovanelli M, Mortini P.

Neurosurg Rev. 2012 Jul;35(3):369-78; discussion 378-9. Epub 2011 Nov 15.

Results of Gamma Knife Radiosurgery in Acromegaly
Franzin A, Spatola G, Losa M, Picozzi P, Mortini P.

Int J Endocrinol. 2012;2012:342034

The history of the hypophysis: the pioneering studies of Edoardo Gemelli
Riva M, Cosmacini G, Mortini P.

Neurosurgery. 2011 Jun;68(6):1483-998.

Neurosurgical treatment of craniopharyngioma in adults and children: early and long-term results in a large case series
Mortini P, Losa M, Pozzobon G, Barzaghi LR, Riva M, Acerno S, Angius D, Weber G, Chiumello G, Giovanelli M.

J Neurosurg. 2011 May;114(5):1350-9.

Salvage therapy with Temozolomide in patients with aggressive or metastatic pituitary adenomas: experience in six cases
Losa M, Mazza E, Terreni MR, McCormack A, Gill AJ, Motta M, Cangi MG, Talarico A, Mortini P, Reni M.

Eur J Endocrinol. 2010 Dec; 163(6):843-51.

Pituitary radiotherapy for Cushing’s disease
Losa M, Picozzi P, Redaelli MG, Laurenzi A, Mortini P.

Neuroendocrinology. 2010;92 Suppl 1:107-10. Epub 2010 Sep 10

Longitudinal splitting of optic pathways by non-functioning pituitary macroadenomas: report of two cases
Gagliardi F, Boari N, Losa M, Mortini P.

Acta Neurochir (Wien). 2010 Jun;152(6):1065-895.

Anterior Cranial Base Reconstruction
Brusati R, Biglioli F, Mortini P

Cranial, Craniofacial and Skull Base Surgery. Springer- Verlag Italia 2010. Cap 23, pp 331-342.

Delayed remission after transsphenoidal surgery in patients with Cushing’s disease
Valassi E, Biller BM, Swearingen B, Pecori Giraldi F, Losa M, Mortini P, Hayden D, Cavagnini F, Klibanski A. J

Journal Clin Endocrinol Metab. 2010 Feb;95(2):601-10. Epub 2010 Jan 15.

Persistent adrenocorticotropin response to desmopressin in the early postoperative period predicts recurrence of Cushing’s disease
Losa M, Bianchi R, Barzaghi R, Giovanelli M, Mortini P.

J Clin Endocrinol Metab. 2009 Sep;94(9):3322-8. Epub 2009 Jul 7

Thyrotropin-secreting pituitary adenomas: biological and molecular features, diagnosis and therapy
Losa M, Fortunato M, Molteni L, Peretti E, Mortini P.

Minerva Endocrinol. 2008 Dec;33(4):329-40.

The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma.
Losa M, Gioia L, Picozzi P, Franzin A, Valle M, Giovanelli M, Mortini P.

J Clin Endocrinol Metab. 2008 Jul;93(7):2546-52. Epub 2008 Apr 15.

Euclidean and fractal geometry of microvascular networks in normal and neoplastic pituitary tissue
Di Ieva A, Grizzi F, Gaetani P, Goglia U, Tschabitscher M, Mortini P, Rodriguez y Baena R.

Neurosurg Rev. 2008 Jul;31(3):271-81. Epub 2008 Mar 8. Review.

Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence
Losa M, , Barzaghi R, Ribotto P, Terreni MR, Marzoli SB, Pieralli S, Giovanelli M.

J Neurosurg. 2008 Mar;108(3):525-32.

Complication of transsphenoidal surgery in patients with pituitary adenoma: experience at a single center
Barzaghi LR, Losa M, Giovanelli M, Mortini P.

Acta Neurochirur 2007;149(9):877-85.

Surgical treatment of giant pituitary adenomas: strategies and results in a series of 95 consecutive patients
Mortini P, Barzaghi LR,Losa M,Boari N,Giovanelli M.

Neurosurgery, June,2007; 60 (6), 993-1002.

Intrasellar paraganglioma: a case report and review of the literature.
Boari N, Losa M, Mortini P, Snider S, Terreni MR, Giovanelli M.

Acta Neurochir (Wien). 2006 Dec;148(12):1311-4.

Presurgical treatment with somatostatin analogs in patients with acromegaly: effects on the remission and complication rates
Losa M, Mortini P, Urbaz L, Ribotto P, Castrignano’ T Giovanelli M.

J Neurosurg. 2006 Jun;104(6):899-906

Coexistence of TSH-secreting pituitary adenoma and autoimmune hypothyroidism
Losa M, Mortini P, Minelli R, Giovanelli M.

J Endocrinol Invest. 2006 Jun;29(6):555-9.

Obstructive hydrocephalus and intracranial hypertension caused by a giant macroprolactinoma. Prompt response to medical treatment
Scarone P, Losa M, Mortini P, Giovanelli M

J Neurooncol. 2006 Jan;76(1):51-4.

A non –functioning pituitary adenoma initially mimicking a microprolactinoma: The case of long term follow-up of patients with hyperprolactinemia?
Losa M, Mortini P, Giovanelli M.

J Endocrinol Invest.2005 Apr; 28(4):36-70.

Results of transsphenoidal surgery in a large series of patients with pituitary adenoma
Mortini P, Losa M, Barzaghi R, Boari N, Giovanelli M

Neurosurgery 2005 June;56(6);1222-1223

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenoma
Picozzi P, Losa M., Mortini P, Valle MA, Franzin A, Attuati L, Ferrari Da Passano C, Giovanelli M

J Neurosurgery.2005 Jan;102 Suppl:71-4.

Correlation between clinical characteristics and proliferative activity in patients with craniopharyngiomas
Losa M, Vimercati A, Acerno S, Barzaghi R, Mortini P, Mangili F, Terreni MR, Santambrogio G, Giovanelli M.

Journal of Neurology Neurosurgery and Psychiatry 2004 June;75(6):889-92

Gamma Knife surgery for treatment of residual nonfunctioning pituitary adenomas after surgical debulking
Losa M., Valle M., Mortini P., Franzin A., Ferrari da Passano C., Cenzato M., Bianchi S., Picozzi P., Giovanelli M.

Journal of Neurosurgery 2004 Mar;100(3) :438-444.R

Thyreotropin-produzierende Hypophysenadenome

Terapieletfaden Hypophysenrkrankungen, Uni-Med Verlag Bremen 2004 Cap 7, pp 77-82.

Corticotrophin-releasing activity of desmopressin in Cushing’s disease: lack of correlation between in vivo and in vitro responsiveness
Pecori Giraldi F,Marini E,Torchiara E, Mortini P, Dubini A, Cavagnini F.

J Endocrinol. 2003 Jun;177(3):373-9.

Insulin action on protein metabolism in acromegalic patients
Battezati A,Benedini S,Fattorini A,Losa M, Mortini P, Bertoli S, Lanzi R, Testolin G, Biolo G, Luzi L.

American Journal of Physiology endocrinology and metabolism. 2002 Oct 8

Surgical treatment of prolactin-secreting pituitary adenomas: early results and long-term outcome
Losa M, Mortini P, Barzaghi R, Gioia L, Giovanelli.

J Clin Endocrinol Metab. 2002 Jul;87(7):3180-6.

The “High Mobility” Group 2 gene is amplified and overexpressed in Human Prolactinomas
Finelli P, Pierantoni GM, Giardino D, Losa M, Rodeschini O, Fedele M, Valtorta E, Mortini P, Croce CM,Larizza L, Fusco A.

Cancer Research 62,2398-2405, April 2002

Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery
Gemma M, Tommasino C, Cozzi S, Narcisi S, Mortini P, Losa M, Soldarini A.

Anesth Analg. 2002 Jan;94(1):163-8,

La via transnasosfenoidale

Papo I,Villani R,Giovanelli Barilari M,Gaini SM. Neurochirurgia Clinica. Cap 53 III pp 999-1005 Edizioni Medico Scientifiche Torino 2002

Lesioni sellari e parasellari

Neurochirurgia Clinica. Cap 30 pp 457-474 Edizioni Medico Scientifiche Torino 2002. Papo I,Villani R,Giovanelli Barilari M,Gaini SM.

Endocrine inactive and gonadotroph adenomas: diagnosis and management
Losa M, Mortini P, Barzaghi R, Franzin A, Giovanelli M. J

Neuro-oncology 2001 Sept 54 (2):167-177.

Desmopressin stimulation test before and after pituitary surgery in patients with Cushing’s disease
Losa M, Mortini P, Dylgjeri S, Barzaghi R, Franzin A, Mandelli C, Giovanelli M.

Clinical Endocrinology 55:61-68,2001.

Effects of octreotide treatment on the proliferation and apoptotic index of GH secreting pituitary adenomas
Losa M,Ciccarelli E, Mortini P, Barzaghi R, Gaia D, Faccani G, Papotti M, Mangili F, Terreni MR, Camanni F, Giovanelli M. J Clini

J Clin Endocrinol Metab 2001 Nov;86(11):5194-5200

La terapia chirurgica dell’acromegalia
Giovanelli M,Losa M,Mortini P.

Liuzzi A,Opizzi G; La malattia acromegalica, pp 71-88.Ed.Pubblicazioni medico scientifiche 2001.

Proliferation index of Nonfunctioning pituitary adenomas: correlations with clinical characteristics and long-term follow-up results
Losa M, Franzin A, Mangili F, Terreni MR, Barzaghi R, Veglia F, Mortini P, Giovanelli M.

Neurosurgery 47:1313-1319,2000

Determination of the proliferation and Apoptotic index in adrenocorticotropin-secreting pituitary tumors: Comparison between micro and macroadenomas
Losa M, Barzaghi RLA, Mortini P, Franzin A, Mangili F, Terreni MR, Giovanelli M.

American Journal of Pathology 2000,156:245-251.

Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study
Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M.

Journal of Neurosurgery 93,121-126, 2000.

Thyrotropin receptor protein expression in normal and adenomatous human pituitary
Theodoropulos M, Arzberger T, Gruebler Y, Korali Z, Mortini P, Joba W, Heufelder AE, Stalla GK, Shaaf L.

Journal of Endocrinology 167,7-13,2000.

Surgical Management of Thyrotropin-Secreting Pituitary Adenomas.
Losa M, Mortini P, Franzin A, Barzaghi R, Mandelli C, Giovanelli M.

Pituitary Vol 2,: 127-131,1999.

Is presurgical treatment with somatostatin analogs necessary in acromegalic patients?
Mortini P, Giovanelli M.

Journal of Endocrinological Investigation 22:871-873,1999

Usefulness of markers of cell proliferation in the management of pituitary adenomas
Losa M, Franzin A, Mortini P, Terreni MR, Mangili F, Giovanelli M.

Clinical Science 95 (1998) 129-135.

Differentiation of clinically non-functioning pituitary adenomas from meningiomas and craniopharyngiomas by positron emission tomography with [18F]fluoro-ethyl-spiperone
Lucignani G, Losa M, Moresco RM, Del Sole A, Matarrese M, Bettinardi V, Mortini P, Giovanelli M, Fazio F.

European Journal of Nuclear Medicine 24 (1997) 1149-1155.

Indium-111 pentetreotide single-photon emission tomography in patients with TSH-secreting pituitary adenomas: correlation with the effect of a single administration of octreotide on serum TSH levels
Losa M, Magnani P, Mortini P, Persani L, Acerno S, Giugni E, Songini C, Fazio F, Beck-Peccoz P, Giovanelli M

European Journal of Nuclear Medicine 24 (1997) 728-731

Metastatic prostatic adenocarcinoma presenting as a pituitary mass: Shrinkage of the lesion and clinical improvement with medical treatment
Losa M, Grasso M, Giugni E, Mortini P, Acerno S, Giovanelli M.

Prostate 1:32(4) (1997) 241-245

Surgical therapy of pituitary adenomas
Giovanelli M, Losa M, Mortini P.

Metabolism Clinical & Experimental 45 Suppl. 1 (1996): 115-116

Il controllo della carotide intracranica.
Mortini P, Giugni E,Mandelli CM,Franzin A,Giovanelli M. In Chiesa R,Melissano G,

La chirurgia dei Tronchi Sopra Aortici Cap 54,pp 479- 487. Ed. Europa Scienze Umane 1997.

Surgical results in microadenomas
Giovanelli M, Losa M, Mortini P, Acerno S, Giugni E.

Acta Neurochir Suppl. 65 (1996) : 11-12

Criteria of cure and follow-up of central hyperthyroidism due to thyrotropin-secreting pituitary adenomas
Losa M, Giovanelli M, Persani L, Mortini P, Faglia G, Beck-Peccoz P.

Journal of Clinical Endocrinology and Metabolism 81 (1996): 3084-3090

Surgical treatment of acromegaly
Giovanelli M, Mortini P, Giugni E, Acerno S, Losa M. In: von Werder K, Fahlbusch R

Pituitary adenomas: from basic research to diagnosis and therapy, Elsevier, Amsterdam, pp 21-30, 1996.

Acromegaly: surgical results and prognosis
Giovanelli M, Losa M, Mortini P. In: Landolt AM, Vance ML, Reilly PL

Pituitary adenomas. Churchill Livingstone, Edinburgh, 1996, pp 333-351.

Widened transnasal surgical approach for removal of huge, forward-spreading pituitary neoplasms.
Antonelli AR, Cappiello J, Bigoni AG, Puxeddu R, Mortini P, Losa M, Giovaneli M. in: Mazzoni A, Sanna M

Skull base surgery - Kugler publications, Amsterdam, New York, pp 229-235, 1995.

Responsiveness of gonadotropins to TRH in patients with nonfunctioning pituitary adenomas: correlation with immunoistochemical results.
Losa M, Terreni MR, Mortini P, Acerno S, Giovanelli M

Frontiers in Endocrinology, Highlights in Molecular and Clinical Endocrinology, Vol. 9, pp 155-158, 1994.